anticancer effect — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN7060	Methyl oleanonate		PPAR
	3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.		PPAR
T9805	BAY 2666605		PDE
	BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.		PDE
T24730	Roslin 2 bromide	Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2	FAK , p53
	Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects.		FAK , p53
T1801	SR9243		Liver X Receptor
	SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.		Liver X Receptor
T3S1196	Mogroside IV		Others
	Mogrosides IV is a sweet minor cucurbitane glycoside, it exhibits maltase inhibitory effect(IC50 : 10 mM), and with antioxidant, antidiabetic and anticancer activities.		Others
T7441	Cuminaldehyde	Cuminic aldehyde,Cuminal	Endogenous Metabolite
	Cuminaldehyde (Cuminal) is a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity,with a pleasant smell and contributes to the aroma of essenti...		Endogenous Metabolite
T36646	Trastuzumab deruxtecan	DS-8201a,VRN-101099,DS 8201,T-DXd	Others
	Trastuzumab deruxtecan (T-DXd) is an antibody-activated molecule coupling (ADC) with anticancer and antitumour activity.Trastuzumab deruxtecan has been shown to have an ameliorative effect in HER2-positive breast and gas...		Others
T10390	Asperphenamate		Others , Antifungal
	Asperphenamate is a fungal metabolite of Aspergillus flatiipes. The IC50s for T47D cells, MDA-MB-231 cells, and HL-60 cells are 92.3 μM, 96.5 μM, and 97.9 μM. Asperphenamate shows an anticancer effect.		Others , Antifungal
T5724	Neogambogic acid	neo-gambogic acid	Apoptosis , Others , Antibacterial
	Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell li...		Apoptosis , Others , Antibacterial
TN1727	Helichrysetin		Apoptosis , HIV Protease
	Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.		Apoptosis , HIV Protease
T5S1285	(+)-(3R,8S)-Falcarindiol	Falcarindiol	Others
	1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a nov...		Others
T72064	TASK-1-IN-1		Potassium Channel
	TASK-1-IN-1 is a potent and selective inhibitor of TASK-1 (Potassium Channel) (IC50: 148 nM).TASK-1-IN-1 has a reduced inhibitory effect on the TASK-3 channel with an IC50 of 1750 nM.TASK-1-IN-1 has anticancer effects.		Potassium Channel
T71703L	Isomer-Turosteride	Isomer-Turosteride(Isomer-137099-09-3)	Reductase
	Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) is a novel 5 alpha-reductase inhibitor.The antiprostatic effect of Isomer-Turosteride in adult rats is associated with the inhibition of the conversion of T to ...		Reductase
T3339	Sophoridine	5-Epidihydrosophocarpine,Dihydro-5-episophocarpine	Apoptosis , Topoisomerase
	Sophoridine (Dihydro-5-episophocarpine), a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity ...		Apoptosis , Topoisomerase
T3S0081	Oxypeucedanin	(+-)-Oxypeucedanin,Oxypeucadanin	Potassium Channel
	1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocke...		Potassium Channel
T3398	Icaritin	Anhydroicaritin,Cycloicaritin	Apoptosis , JAK , STAT , Autophagy
	Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica...		Apoptosis , JAK , STAT , Autophagy
T3895	Polyphyllin I		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
	Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha...		Apoptosis , Akt , JNK , PDK , mTOR , Autophagy
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T2S1865	Octyl gallate	Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8	Antioxidant , Influenza Virus , Reactive Oxygen Species , Antibacterial , Antifungal , HSV
	1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, ...
T26285	TPMP-I-2	TPMP-I 2,TPMP-I2
	TPMP-I-2 has an anticancer effect of immunotoxins.